Publications
1.
Lee J, Lim CG, Vairaprakash P, Kim JM, Kim J, Park JY, Hahn KM, Shim H, Choi HW, Ulmer TS, Hong SJ, Kim CSelective Inhibition of Integrin β3 Topology Provides a Safer Antithrombotic Strategy.Adv Sci 2026 Apr 13; :e22086PubMed 2.
Lim CG, Lee J, Suk G, Kim JM, Shim H, Choi HW, Park JY, Hong SJ, Kim CRecombinant haemostatic protein for therapeutic substitution of platelet function via tripartite haemostatic mechanisms in thrombocytopenic male mice.Nat Commun. 2026 Apr 1; PubMed 3.
Park JS, Lee IB, Moon HM, Jeon H, Lee M, Kim C, Hong SC, Cho MNanoscopy of Organelle Handoff Portals Reveals Direct Coupling between Endoplasmic Reticulum Remodeling and Microtubule-Based Transport.ACS nano 2026 Mar 17; 20(10):8309-8320PubMed 4.
Vu HN*, Lee M*, Situ AJ, An W, Ley K, Kim C#, Ulmer TS#.Functional unfolding of the integrin αX transmembrane helix.Proc Natl Acad Sci U S A. 2025 Sep 23; 122(38):e2507966122PubMed 5.
Yoon MJ, Park J, Lee M, Ohk J, Choi TS, Choi EJ, Jung H, Kim C.UXT oligomerization is essential for its role as an autophagy adaptor.iScience. 2025 Feb 13;; 28(3):112013.PubMed 6.
Pham AVQ, Na Y, Suk G, Yang C, Kang SM, Lee J, Choi H, Kim W, Chi SW, Han S, Choi HW, Kim H, Kim C.Identification of Tie2 as a sensor for reactive oxygen species and its therapeutic implication.Redox Biol. 2025 Feb 20.; 81:103555.PubMed 7.
Ha T, Kang B, Kim MS, Chu JW, Kim K, Yoon W, Kim SH, Kang T, Kim MS, Kim C, Cha JY, Oh U, Han K, Choi CW, Hong GS.Uncaria Rhynchophylla and hirsuteine as TRPV1 agonists inducing channel desensitization.J Ethnopharmacol. 2025 Jan 30.; 337(Pt 2):118869.PubMed 8.
Lee PR, Ha T, Choi HS, Lee SE, Kim C, Hong GS.Piezo1 mediates mechanical signals in TRPV1-positive nociceptors in mice.Acta Physiol 2024 Nov.; 240(11):e14236.PubMed 9.
Jang J, Park HJ, Seong W, Kim J, Kim C.Vimentin-mediated buffering of internal integrin β1 pool increases survival of cells from anoikisBMC Biol. 2024 Jun 24; 22(1):139.PubMed 10.
Lee J, Lee M, Kim J, Cho EG, Kim C.Producing highly effective extracellular vesicles using IBAR and talin F3 domain fusion.Anim Cells Syst (Seoul). 2024 May 18; 28(1):283-293PubMed 11.
Lee KS, Kim Y, Lee JH, Shon S, Kim A, Pham AVQ, Kim C, Kim DH, Kim YK, Cho EG.Human Probiotic Lactobacillus paracasei-Derived Extracellular Vesicles Improve Tumor Necrosis Factor-α-Induced Inflammatory Phenotypes in Human Skin.Cells. 2023 Dec 7; 12(24):2789PubMed 12.
Naskar M, Parekh VP, Abraham MA, Alibasic Z, Kim MJ, Suk G, Noh JH, Ko KY, Lee J, Kim C, Yoon H, Abraham SN, Choi HW.α-Hemolysin promotes uropathogenic E. coli persistence in bladder epithelial cells via abrogating bacteria-harboring lysosome acidificationPLoS Pathog. 2023 May 11; 19(5):e1011388PubMed 13.
Jang J*, Cho EH*, Cho Y, Ganzorig B, Kim KY, Kim MG, Kim C.Environment-Sensitive Ectodomain Shedding of Epithin/PRSS14 Increases Metastatic Potential of Breast Cancer Cells by Producing CCL2.Mol Cells. 2022 Aug 31; 45(8):564-574.PubMed 14.
Hwang J, Jang B, Kim A, Lee Y, Lee J, Kim C, Kim J, Moon KM, Kim K, Wagle R, Song YH, Oh ES.Syndecan Transmembrane Domain Specifically Regulates Downstream Signaling Events of the Transmembrane Receptor Cytoplasmic DomainInt J Mol Sci. 2021 Jul 24; 22(15):7918.PubMed 15.
Chang J, Hwang HJ, Kim B, Choi YG, Park J, Park Y, Lee BS, Park H, Yoon MJ, Woo JS, Kim C, Park MS, Lee JB, Kim YK.TRIM28 functions as a negative regulator of aggresome formation.Autophagy. 2021 Mar 30.; Online ahead of print.PubMed 16.
Yoon MJ*, Choi B*, Kim EJ, Ohk J, Yang C, Choi YG, Lee J, Kang C, Song HK, Kim YK, Woo JS, Cho Y, Choi EJ, Jung H#, Kim C#.UXT chaperone prevents proteotoxicity by acting as an autophagy adaptor for p62-dependent aggrephagy.Nat Commun. 2021 Mar 29;; 12(1):1955.PubMed 17.
Situ AJ*, Kim J*, An W, Kim C#, Ulmer TS#.Insight into pathological integrin αIIbβ3 activation from safeguarding the inactive state.J Mol Biol. 2021 Feb 1; 433(3):166832PubMed 18.
Bang J, Park H, Yoo J, Lee D, Choi WI, Lee JH, Lee YR, Kim C, Koo H, Kim S.Selection and Identification of a Novel Bone-Targeting Peptide for Biomedical Imaging of BoneSci Rep. 2020 Jun 29;; 10(1):10576.PubMed 19.
Lim IR, Kim C, Jung JW, Kim JH, Hong SJ.Inhibition of Smooth Muscle Cell Proliferation and Migration by a Talin Modulator Attenuates Neointimal Formation After Femoral Arterial InjuryKorean Circ J . 2020 Jul;; 50(7):613-624PubMed 20.
Cho Y, Kim SB, Kim J, Pham AVQ, Yoon MJ, Park JH, Hwang KT, Park D, Cho Y, Kim MG, Kim C.Intramembrane proteolysis of an extracellular serine protease, epithin/PRSS14, enables its intracellular nuclear function.BMC Biol. 2020 Jun 3; 18(1):60.PubMed 21.
Yoon J*, Cho Y*, Kim KY, Yoon MJ, Lee HS, Jeon SD, Cho Y, Kim C, Kim MG.A JUN N-terminal kinase inhibitor induces ectodomain shedding of the cancerassociated membrane protease Prss14/epithin via protein kinase CβII.J Biol Chem. 2020 Apr 2.; 295(21):7338-7351PubMed 22.
Kim J, Lee J, Jang J, Ye F, Hong SJ, Petrich BG, Ulmer TS, Kim C.Topological Adaptation of Transmembrane Domains to the Force-Modulated Lipid Bilayer Is a Basis of Sensing Mechanical ForceCurr Biol. 2020 Mar; 30(5):764-772PubMed 23.
Kim KY, Yoon M, Cho Y, Lee KH, Park S, Lee SR, Choi SY, Lee D, Yang C, Cho EH, Jeon SD, Kim SH, Kim C, Kim MG.Targeting Metastatic Breast Cancer With Peptide Epitopes Derived From Autocatalytic Loop of Prss14/ST14 Membrane Serine Protease and With Monoclonal AntibodiesJ Exp Clin Cancer Res. 2019 Aug 19; 38(1):363. PubMed 24.
Lim CG*, Jang J*, Kim C#.Cellular machinery for sensing mechanical force.BMB Rep. 2018 Oct 8. ; 51(12):623-629PubMed 25.
Situ AJ, Kang SM, Frey BB, An W, Kim C#, Ulmer TS#.Membrane Anchoring of α-Helical Proteins: Role of Tryptophan.J Phys Chem B. 2018 Jan 11.; 122(1):118-125PubMed 26.
Cho Y#, Park D, Kim C.Disruption of TACE-filamin interaction can inhibit TACE-mediated ectodomain shedding.Biochem Biophys Res Commun. 2017 Jun 27.; 488(2):296-302PubMed 27.
Ye F*, Yang C*, Kim J, MacNevin CJ, Hahn KM, Park D, Ginsberg MH#, Kim C#Epigallocatechin gallate has pleiotropic effects on transmembrane signaling by altering the embedding of transmembrane domains.J Biol Chem 2017 May 9; 292(30):12577-12584PubMed 28.
Yang C*, Kwon S*, Kim SJ, Jeong M, Park JY, Park D, Hong SJ, Jung JW#, Kim C#.Identification of Indothiazinone as a Natural Antiplatelet Agent.Chem Biol Drug Des. 2017 Apr 22; 90(4):502-511PubMed 29.
Lim IR, Joo HJ, Jeong M, Kim JH, Choi SC, Kim C, Jung JW, Hong SJ.Talin Modulation by a Synthetic N-Acylurea Derivative Reduces Angiogenesis in Human Endothelial Cells.Int J Mol Sci. 2017 Jan 22;18(1).; 18(1):210PubMed 30.
Kim J*, Jang J, Yang C, Kim EJ, Jung H, Kim C#.Vimentin filament controls integrin α5β1-mediated cell adhesion by binding to integrin through its Ser38 residue.FEBS Lett. 2016 Sep 22.; 590(20):3517-3525PubMed 31.
Kim BC, Hwang HJ, An HT, Lee H, Park JS, Hong J, Ko J, Kim C, Lee JS, Ko YG.Antibody neutralization of cell-surface gC1qR/HABP1/SF2-p32 prevents lamellipodia formation and tumorigenesis.Oncotarget. 2016 Jun 24.; 7(31):49972-49985PubMed 32.
Ligarrigue F, Kim C#, Ginsberg MH#.The Rap1-RIAM-talin axis of integrin activation and blood cell function.Blood 2016 May 20; 128(4):479-487PubMed 33.
Yang C*, Ohk J*, Lee JY*, Kim EJ, Kim J, Han S, Park D, Jung H#, Kim C#.Calmodulin Mediates Ca2+-Dependent Inhibition of Tie2 Signaling and Acts as a Developmental Brake During Embryonic Angiogenesis.Arterioscler Thromb Vasc Biol. 2016 May 19.; 36(7):1385-1393PubMed 34.
Kim S, Yang JW, Kim C, Kim MG.Impact of suppression of tumorigenicity 14 (ST14)/serine protease 14 (prss14) expression analysis on the prognosis and management of estrogen receptor negative breast cancer.Oncotarget. 2016 May 4.; 7(23):34141-34151PubMed 35.
Han S, Lee SJ, Kim KE, Lee HS, Oh N, Park I, Ko E, Oh SJ, Lee YS, Kim D, Lee S, Lee DH, Lee KH, Chae SY, Lee JH, Kim SJ, Kim HC, Kim S, Kim S, Kim C, Nakaoka Y, He Y, Augustin HG, Hu J, Song PH, Kim YI, Kim P, Kim I, Koh GY.Amelioration of sepsis by TIE2 activation-induced vascular protection.Sci Transl Med. 2016 Apr 20; 8(335):335ra55.PubMed 36.
Kim J*, Yang C*, Kim EJ, Jang J, Kim SJ, Kang SM, Kim MG, Jung H, Park D, Kim C.Vimentin filaments regulate integrin-ligand interactions by binding to the cytoplasmic tail of integrin β3.J Cell Sci. 2016 Apr 4.; 129(10):2030-2039PubMed 37.
Lee HS, Park BM, Cho Y, Kim S, Kim C, Kim MG, Park D.Shedding of epithin/PRSS14 is induced by TGF-β and mediated by tumor necrosis factor-α converting enzyme.Biochem Biophys Res Commun. 2014 Sep 19.; 452(3):471-477PubMed 38.
Lee HS*, Oh SJ*, Lee KH, Lee YS, Ko E, Kim KE, Kim HC, Kim SG, Song PH, Kim YI, Kim C#, Han S#.Gln362 of Angiopoietin-2 Mediates Migration of Tumor and Endothelial Cells through Association with α5β1 Integrin.J Biol Chem. 2014 Sep 18.; 289(45):31330-31340PubMed 39.
Ye F, Kim SJ, Kim C#.Intermolecular Transmembrane Domain Interactions Activate Integrin αIIbβ3.J Biol Chem. 2014 May 16.; 289(31):21555-21563 PubMed 40.
Li A, Guo Q, Kim C, Hu W, Ye F.Integrin αIIb Tail Distal of GFFKR Participates in Inside-out αIIbβ3 Activation.J Thromb Haemost. 2014 May 16.; 12(7):1155-1163PubMed 41.
Kim C#, Kim MC.Differences in α-β transmembrane domain interactions among integrins enable diverging integrin signaling.Biochem Biophys Res Commun. 2013 Jul 5; 436(3):406-412.PubMed 42.
Tkachenko E, Gutierrez E, Saikin SK, Fogelstrand P, Kim C, Groisman A, Ginsberg MH.The nucleus of endothelial cell as a sensor of blood flow direction.Biol Open. 2013 Aug 14; 2(10):1007-1012.PubMed 43.
Kim C*, Ye F*, Hu X, Ginsberg MH.Talin activates integrins by altering the topology of the β transmembrane domain.J Cell Biol. 2012 May 28; 197(5):605-11.PubMed 44.
Kim C*, Schmidt T*, Cho EG, Ye F, Ulmer TS, Ginsberg MH.Basic amino-acid side chains regulate transmembrane integrin signalling.Nature. 2011 Dec 18; 481(7380):209-13.PubMed 45.
Ye F*, Kim C*, Ginsberg MH.Reconstruction of integrin activation.Blood. 2012 Jan 5; 119(1):26-33.PubMed 46.
Ye F*, Kim C*, Ginsberg MH.Molecular mechanism of inside-out integrin regulation.J Thromb Haemost. 2011 Jul; 9 Suppl 1:20-25.PubMed 47.
Kim C*, Ye F*, Ginsberg MH.Regulation of integrin activation.Annu Rev Cell Dev Biol. 2011; 27:321-45.PubMed 48.
Tkachenko E, Sabouri-Ghomi M, Pertz O, Kim C, Gutierrez E, Machacek M, Groisman A, Danuser G, Ginsberg MH.Protein kinase A governs a RhoA-RhoGDI protrusion-retraction pacemaker in migrating cells.Nat Cell Biol. 2011 Jun; 13(6):660-667.PubMed 49.
Kim C*, Lee HS*, Lee D*, Lee SD, Cho EG, Yang SJ, Kim SB, Park D, Kim MG.Epithin/PRSS14 proteolytically regulates angiopoietin receptor Tie2 during transendothelial migration.Blood. 2011 Jan 27; 117(4):1415-1424.PubMed 50.
Kim SB, Lee D, Jeong JW, Kim C, Park D, Kim MG.Soluble epithin/PRSS14 secreted from cancer cells contains active angiogenic potential.Mol Cells. 2010 Jun; 29(6):617-623.PubMed 51.
Lee HS, Kim C, Kim SB, Kim MG, Park D.Epithin, a target of transforming growth factor-beta signaling, mediates epithelial-mesenchymal transition.Biochem Biophys Res Commun. 2010 May 14; 395(4):553-559.PubMed 52.
Shattil SJ, Kim C, Ginsberg MH.The final steps of integrin activation: the end game.Nat Rev Mol Cell Biol. 2010 Apr; 11(4):288-300.PubMed 53.
Anthis NJ, Wegener KL, Ye F, Kim C, Goult BT, Lowe ED, Vakonakis I, Bate N, Critchley DR, Ginsberg MH, Campbell ID.The structure of an integrin/talin complex reveals the basis of inside-out signal transduction.EMBO J. 2009 Nov 18; 28(22):3623-3632.PubMed 54.
Lau TL, Kim C, Ginsberg MH, Ulmer TS.The structure of the integrin alphaIIbbeta3 transmembrane complex explains integrin transmembrane signalling.EMBO J. 2009 May 6; 28(9):1351-1361.PubMed 55.
Kim C, Lau TL, Ulmer TS, Ginsberg MH.Interactions of platelet integrin alphaIIb and beta3 transmembrane domains in mammalian cell membranes and their role in integrin activation.Blood. 2009 May 7; 113(19):4747-4753.PubMed 56.
Prager GW, Feral CC, Kim C, Han J, Ginsberg MH.CD98hc (SLC3A2) interaction with the integrin beta subunit cytoplasmic domain mediates adhesive signaling.J Biol Chem. 2007 Aug 17; 282(33):24477-24484.PubMed 57.
Kim C*, Cho Y*, Kang CH, Kim MG, Lee H, Cho EG, Park D.Filamin is essential for shedding of the transmembrane serine protease, epithin.EMBO Rep. 2005 Nov; 6(11):1045-1051.PubMed 58.
Cho EG, Kim MG, Kim C, Kim SR, Seong IS, Chung C, Schwartz RH, Park D.N-terminal processing is essential for release of epithin, a mouse type II membrane serine protease.J Biol Chem. 2001 Nov 30; 276(48):44581-44589PubMed 59.
Lee KH, Lee SH, Kim D, Rhee S, Kim C, Chung CH, Kwon H, Kang MS.Promotion of skeletal muscle differentiation by K252a with tyrosine phosphorylation of focal adhesion: a possible involvement of small GTPase Rho.Exp Cell Res. 1999 Nov 1; 252(2):401-415.PubMed